Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase

Charles M Marson; Alphonso S Rioja; Greg Brooke; R Charles Coombes; David M Vigushin

doi:10.1016/s0960-894x(01)00718-1

Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase

Bioorg Med Chem Lett. 2002 Jan 21;12(2):255-9. doi: 10.1016/s0960-894x(01)00718-1.

Authors

Charles M Marson¹, Alphonso S Rioja, Greg Brooke, R Charles Coombes, David M Vigushin

Affiliation

¹ Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK. c.m.marson@ucl.ac.uk

PMID: 11755366
DOI: 10.1016/s0960-894x(01)00718-1

Abstract

Cyclic acid anhydrides possessing a lipid chain have been shown to be a new class of non-peptidic inhibitors of geranylgeranyl protein-transferase type I (GGPTase-I).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkyl and Aryl Transferases / antagonists & inhibitors*
Anhydrides / chemistry
Anhydrides / pharmacology*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*

Substances

Anhydrides
Enzyme Inhibitors
Alkyl and Aryl Transferases
geranylgeranyltransferase type-I